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This is a health tool that allows you to compute the total carboplatin dose in mg based on the estimated creatinine clearance level from the cockcroft gault equation and on the targeted. This carboplatin dosing calculator uses the calvert method to calculate the total carboplatin dose needed to achieve a given auc (area under the free carboplatin plasma concentration versus. Carboplatin is supplied as a ready to use.
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In a prospective clinical and pharmacokinetic study the formula was used to determine the dose required to treat 31 patients (gfr range, 33 to 135 ml/min) with 40. The fda has recommended that providers consider capping the dose of. Global rph is a website that provides various calculators and indexes for medical and pharmaceutical purposes.
We compared these formulae to identify patient profiles that were associated with significant carboplatin dose variation by retrospectively analysing the carboplatin dosing of 96 patients.
Developed by best wr, et al. In 1976 at the midwest regional health center in illinois to assess patient's with crohn's disease using an index consisting of 8 factors along with weighting. Heart failure, ischemic heart disease, or any major comorbidity can have a moderate to high impact on mortality rates. Data from 121 patients with alcoholic hepatitis (ah) from january 2000 through january 2008 were studied in order to develop a prognostic model that could predict the risk of.
A new reporting section was added as well to the results section. Globalrph provides information on carboplatin, a cancer chemotherapeutic agent, including dosage, dilution, stability, and warnings. Renal failure, liver failure, or disseminated malignancy carry the. The calvert formula (1) established a dosage.
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Use this carboplatin calculator to quickly determine the appropriate dose of chemotherapy based on your renal function.
One of the calculators is for carboplatin area under the curve. Medical calculators for the clinician, comprehensive guide to drug therapy, intravenous iv drug dilution, dosing calculators, nutrition and diet calculators Directly measured glomerular filtration rate (mgfr [ml/min]) is the preferred kidney function value in the calvert formula, especially where estimated kidney function may be unreliable for. Adjusted body weight (ajbw) and dose will be displayed for overweight or obese patients (bmi ≥ 25 kg/m 2).
Approximately 70% of carboplatin is excreted in the urine unchanged after 24 hours, therefore dosing needs to account for renal function.
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